Gene information
Official symbol TNFSF10
Official full name TNF superfamily member 10
Gene type protein-coding gene
Chromosome3q26
Alias symbolTRAIL; Apo-2L; TL2; CD253
Gene familyCD molecules; Tumor necrosis factor superfamily
Resources
Entrez Gene 8743
HGNC HGNC:11925
Ensembl ENSG00000121858
Vega OTTHUMG00000156917
UCSC uc003fid.3
GO terms: 28 records
GO Description Category LogP Number of genes Detail
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0005126 cytokine receptor binding GO Molecular Functions -41.4908940 50 More
GO:0005164 tumor necrosis factor receptor binding GO Molecular Functions -5.56986570 6 More
GO:0010638 positive regulation of organelle organization GO Biological Processes -6.49207636 47 More
GO:0010821 regulation of mitochondrion organization GO Biological Processes -7.09757912 23 More
GO:0010822 positive regulation of mitochondrion organization GO Biological Processes -5.15923818 8 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0010950 positive regulation of endopeptidase activity GO Biological Processes -13.2452311 34 More
GO:0010952 positive regulation of peptidase activity GO Biological Processes -14.1524623 37 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0032813 tumor necrosis factor receptor superfamily binding GO Molecular Functions -5.47819787 7 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO Biological Processes -11.0338596 16 More
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO Biological Processes -14.7594418 39 More
GO:0045862 positive regulation of proteolysis GO Biological Processes -17.3242033 33 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:2000116 regulation of cysteine-type endopeptidase activity GO Biological Processes -14.4496812 41 More
GO:2001056 positive regulation of cysteine-type endopeptidase activity GO Biological Processes -11.1582582 17 More
GO:2001233 regulation of apoptotic signaling pathway GO Biological Processes -35.8481080 51 More
GO:2001235 positive regulation of apoptotic signaling pathway GO Biological Processes -13.4065813 30 More
GO:2001236 regulation of extrinsic apoptotic signaling pathway GO Biological Processes -20.7647111 26 More
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway GO Biological Processes -7.00132107 13 More
KEGG pathways: 10 records
KEGG Description Category LogP Number of genes Detail
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04061 Viral protein interaction with cytokine and cytokine receptor KEGG Pathway -30.3399237 29 More
hsa04068 FoxO signaling pathway KEGG Pathway -6.87449445 21 More
hsa04210 Apoptosis KEGG Pathway -6.60042966 12 More
hsa04217 Necroptosis KEGG Pathway -8.49909048 15 More
hsa04650 Natural killer cell mediated cytotoxicity KEGG Pathway -3.46704202 8 More
hsa05130 Pathogenic Escherichia coli infection KEGG Pathway -9.84822677 18 More
hsa05132 Salmonella infection KEGG Pathway -7.42305681 17 More
hsa05164 Influenza A KEGG Pathway -16.0885267 23 More
hsa05417 Lipid and atherosclerosis KEGG Pathway -33.3876857 40 More
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
tumor necrosis factor ligand superfamily member 10 proteomics left ventricular ejection fraction[other] acute ST elevation myocardial infarction Teringova E et al. Biomed Res Int. 2018
tumor necrosis factor ligand superfamily member 10 proteomics myocardial infarction[diagnosis] myocardial infarction Ajala O et al. Respir Med. 2018
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